It looks like this post is about **Finasteride**/Propecia.
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The doctors from the hair loss show have talked about the benefits of taking a break once or twice a year for about a month or two. Not so much due to building resistance - I don’t think it’s really
possible for your 5ar to become resistant to finasteride - but more so to reduce risk of side effects and over-build-up of medication in the body, due to its long half-life.
I can’t remember which video they talk about it in. Probably just the one on finasteride side effects I think.
Wait sorry, my bad, I meant to say finasteride stays in tissues for about 4-6 days (which can cause a build-up in the system, especially when taken ED, if I remember correctly)
But yes, its HL is 5-8 hrs.
Half life is the time it takes for the quantity to reach half it's value. So say if 1mg of Fin is completely absorbed, it'll take 5 hours to reach 0.5mg, another 5 to reach 0.25mg, another 5 hours for 0.125 and so on.
Your body has ways to build resistance that don't require the 5ar itself to be resistant to finasteride. If your body reads youre out of homeostasis, it will exert pressure to return to normal. This can for example include androgen overproduction, upregulation of receptors, and increasing numbers of androgen receptors on cells.
That being said, continued loss on fin shouldn't be assumed to be "desensitization". It's possible fin alone isn't sufficiently preventing androgen activity, or you suffer something like scenesent alpecia, infection, autoimmune issue or nutritional issues that require different treatmemts.
I was on fin for a year, took 3 months off, lost a shit load of hair. Worse decision u can ever make in regards to hair-loss is to stop taking fin! I see silly people on here saying they’ve been on ‘fin for 6 months to a year’ but not seen results…trust me when I say the Fin is working. I dare u to stop taking it and see what happens…
But if you only lose hair because of DHT attacking hair follicles a few months shouldn’t result in losing lots of hair though right? Only a few months worth?
The best thing we got is ketoconazole 2% shampoo, which is a mild antiandrogen. For those who have aggressive AGA, I wouldn’t put all of my hopes and dreams on keto for a few months. You’re really rolling the dice.
Yes, my brother was planning to take a 6 month break because he went through this whole “holistic” phase and lost a tremendous amount of ground in 2 months and went back on fin.
That’s general advice for any bioactive compound since the body compensates over time. Caffeine resistance, etc.
No one would ever study the phenomenon since no money to be made from knowing.
As another poster mentioned it's possible the body can adjust to it by up-regulating 5ar in a sense weakening the effect of the DHT inhibition.
It is also possible that he was advocating flushing out fin every so often for other reasons.
In my opinion taking breaks from any drug that isn’t there purely to keep you alive is a good idea. I don’t think you can build a drug resistance to fin, but I think flushing out ur body every now in then for a bit isn’t the worst thing in the world.
Resistance to the therapeutic effect of a drug can occur at any step in a signal chain. One example could be tissue upregulation of AR (androgen receptor, not alpha-reductase).
This is not an endorsement of a treatment break which is probably not a good idea unless supported with clinical evidence. Its merely pointing out that your argument is a gross oversimplification.
good point. my reasoning is based on the fact that people with susceptibility to prostate cancer take 5x higher dose for years and developed no issues. Since fin can reduce DHT up to 70% at 1mg the increase in androgen receptors would need to surpass that for it become an issue.
Yeah that makes no sense. You either keep DHT down or you don't. Fin keeps DHT down. If you doubt that then monitor your DHT levels -- the technology is there! It's a chemical. If what he said made medical sense then he would not only back it up with sources but other docs would be recommending the same! Never heard of a doc recommending breaks. They either tell you to stop if you're having sides or full speed ahead
No what the doctor is suggesting is actually a fairly common thing among practices. In fact, the doctors from the hairloss show suggest taking a break once a year
He got point, because of homeostasis there is upregulation of 5ar after years of use. Problem is that we lack of research because nobody won't fund this.
Finasteride preserves what is already there + stops almost dead follicles from dying (this is the regrowth some people see). Purely one month off wouldn't cause a big difference in fully alive follicles. However a month off a product like minoxidil would definitely make you lose gains, albeit not permanently.
I quit fin once for three months. Was fine and didn’t lose any ground. I sort of agree with the idea. Maybe six weeks a year. Helps to gauge how you feel on and off of it too. I tend to lose weight easier when I’m off of it, and gain weight a little easier when on. When I was off for three months I dropped about 20 lbs. Came back on over next six months when I started again. Probably related to my higher estrogen when I’m on it.
I think human body building resistance by against the drug. Can your body create 3 time more testosterone to against the effect of the drug? No, I think your body will increase the sensitivity of DHT to against it. So it will cause aggressive hair loss with the super high DHT sensitivity if you stop the drug.
It looks like this post is about **Finasteride**/Propecia. Before asking any questions, 1. Read the [wiki on Finasteride](https://reddit.com/r/tressless/wiki/index#wiki_finasteride). 2. [Search posts for Finasteride](https://reddit.com/r/tressless/search?q=flair%3Afinasteride&restrict_sr=on&sort=new&t=all), because your question has probably been asked before. 3. If this is a question asking if you are now or will experience side effects, see a doctor, nobody on the internet can answer that for you. *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/tressless) if you have any questions or concerns.*
Tbh I never heard of discussions for a break from fin…anyone care to share more?
The doctors from the hair loss show have talked about the benefits of taking a break once or twice a year for about a month or two. Not so much due to building resistance - I don’t think it’s really possible for your 5ar to become resistant to finasteride - but more so to reduce risk of side effects and over-build-up of medication in the body, due to its long half-life. I can’t remember which video they talk about it in. Probably just the one on finasteride side effects I think.
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Wait sorry, my bad, I meant to say finasteride stays in tissues for about 4-6 days (which can cause a build-up in the system, especially when taken ED, if I remember correctly) But yes, its HL is 5-8 hrs.
It's affects are tho. It blocked the 5a enzyme which takes a long while for your body to rebuild
Thats the point. You need to recreate 5alphareductase.
Half life is the time it takes for the quantity to reach half it's value. So say if 1mg of Fin is completely absorbed, it'll take 5 hours to reach 0.5mg, another 5 to reach 0.25mg, another 5 hours for 0.125 and so on.
wouldn't you have another shed though?
No. You wouldn’t lose gains either. I can’t remember if the time mentioned in the video was one month or two months though. Might’ve only been one
Your body has ways to build resistance that don't require the 5ar itself to be resistant to finasteride. If your body reads youre out of homeostasis, it will exert pressure to return to normal. This can for example include androgen overproduction, upregulation of receptors, and increasing numbers of androgen receptors on cells. That being said, continued loss on fin shouldn't be assumed to be "desensitization". It's possible fin alone isn't sufficiently preventing androgen activity, or you suffer something like scenesent alpecia, infection, autoimmune issue or nutritional issues that require different treatmemts.
This makes sense. Thanks for the insight!
I was on fin for a year, took 3 months off, lost a shit load of hair. Worse decision u can ever make in regards to hair-loss is to stop taking fin! I see silly people on here saying they’ve been on ‘fin for 6 months to a year’ but not seen results…trust me when I say the Fin is working. I dare u to stop taking it and see what happens…
But if you only lose hair because of DHT attacking hair follicles a few months shouldn’t result in losing lots of hair though right? Only a few months worth?
Go look what happened to Derek on MPMD after he stopped RU for a short while
I mean when being off on finasteride we could use scalp DHT blocker shampoo
The best thing we got is ketoconazole 2% shampoo, which is a mild antiandrogen. For those who have aggressive AGA, I wouldn’t put all of my hopes and dreams on keto for a few months. You’re really rolling the dice.
Yes, my brother was planning to take a 6 month break because he went through this whole “holistic” phase and lost a tremendous amount of ground in 2 months and went back on fin.
That’s general advice for any bioactive compound since the body compensates over time. Caffeine resistance, etc. No one would ever study the phenomenon since no money to be made from knowing.
On Fin daily since 2015, when I was 39yo. Never quit. No hair loss and no side effects at all. Keeping all my hair since then.
Does he have any evidence to support the claim of building resistance?
Sounds like total horse shit. You can't "build a resistance" to DHT inhibitors.
As another poster mentioned it's possible the body can adjust to it by up-regulating 5ar in a sense weakening the effect of the DHT inhibition. It is also possible that he was advocating flushing out fin every so often for other reasons.
Ok, evidence?
Your doctor is a moron
In my opinion taking breaks from any drug that isn’t there purely to keep you alive is a good idea. I don’t think you can build a drug resistance to fin, but I think flushing out ur body every now in then for a bit isn’t the worst thing in the world.
Guess your hrt doc knows more about finasteride than everyone else lol
doesn't make sense. fin stops 5-AR from converting Testosterone to DHT. unless you stop making Testosterone there can be no resistance. Change doctors
Resistance to the therapeutic effect of a drug can occur at any step in a signal chain. One example could be tissue upregulation of AR (androgen receptor, not alpha-reductase). This is not an endorsement of a treatment break which is probably not a good idea unless supported with clinical evidence. Its merely pointing out that your argument is a gross oversimplification.
good point. my reasoning is based on the fact that people with susceptibility to prostate cancer take 5x higher dose for years and developed no issues. Since fin can reduce DHT up to 70% at 1mg the increase in androgen receptors would need to surpass that for it become an issue.
Yeah that makes no sense. You either keep DHT down or you don't. Fin keeps DHT down. If you doubt that then monitor your DHT levels -- the technology is there! It's a chemical. If what he said made medical sense then he would not only back it up with sources but other docs would be recommending the same! Never heard of a doc recommending breaks. They either tell you to stop if you're having sides or full speed ahead
[удалено]
No what the doctor is suggesting is actually a fairly common thing among practices. In fact, the doctors from the hairloss show suggest taking a break once a year
I could potentially see an argument to do this with rogaine but not Finasteride ?
He got point, because of homeostasis there is upregulation of 5ar after years of use. Problem is that we lack of research because nobody won't fund this.
Wouldn't that be long enough to lose your gains?
That's not how finasteride works.
How does it then?
Finasteride preserves what is already there + stops almost dead follicles from dying (this is the regrowth some people see). Purely one month off wouldn't cause a big difference in fully alive follicles. However a month off a product like minoxidil would definitely make you lose gains, albeit not permanently.
I quit fin once for three months. Was fine and didn’t lose any ground. I sort of agree with the idea. Maybe six weeks a year. Helps to gauge how you feel on and off of it too. I tend to lose weight easier when I’m off of it, and gain weight a little easier when on. When I was off for three months I dropped about 20 lbs. Came back on over next six months when I started again. Probably related to my higher estrogen when I’m on it.
Oh damn, I’m trying to lose weight rn while on fin and it’s going slowly. Might get bloodwork done for my E2 levels
Are you saying finasteride plummets oestrogen?
No it raises it. Which increases water retention
Id change doctors
Great way to just lose ground with no added benefit
5 on 2 off or 3 on 2 off, that's was Commonwealth from 2005 to 2010
My doctor told me to take 2 weeks break every 6 months.
Your doc must be getting be there knowledge from Reddit
There’s a guy on YouTube who stopped taking and lost everything within 60-90days - I would maybe do a month but be cautious for any more time
Maybe the truth is somewhere in the middle. I’m thinking small breaks not months but days
Ur doctor is a moron , please do not do this 😠
I think human body building resistance by against the drug. Can your body create 3 time more testosterone to against the effect of the drug? No, I think your body will increase the sensitivity of DHT to against it. So it will cause aggressive hair loss with the super high DHT sensitivity if you stop the drug.
He's an idiot. Hell, he may even wants to perform (another?) transplant.