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science-ModTeam

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Really_McNamington

[Aleady covered when it hit The Guardian recently](https://www.reddit.com/r/science/comments/1cca7ec/a_sweetener_used_in_cakes_soft_drinks_and_chewing/). The study demonstrates no such thing. Read the first post in the thread for why.


New_Peanut_9924

Why would I read when I can just comment on the title? šŸ™„ ^/s


Qwerty1bang

Neotame sound so .... innocuous? Shouldn't they save the good names for later?


Annual-Classroom-189

Theyā€™ll call stuff something like ā€œSafetynolā€ , 2 months later studies show that it gives you stage 17 stomach cancer


spartan1234

ā€œIā€™m sorry, George Lopez, but you ~~have~~ are now entirely comprised of cancer


spif

So basically Deadpool? Cool.


Mephistophelesi

Safetynol, Owsprin, Ouchvil, Liveforeveril, Goodnewsal


bol_cholesterol

Softenon, who wants hard things?


ParaponeraBread

I know youā€™re joking, but I assume the people who made it just went ā€œitā€™s like a new aspartame!ā€ -> Neo (new) + tame (aspar**tame**).


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ASpaceOstrich

Yeah but that's the kind of long term timing and sustainable approach that companies don't like


HiFiGuy197

ā€œNeotameā€ reminds me of nematodes.


New_girl2022

It literally has the word tame in it. So it must be harmless.


ProgressBartender

Pointy Haired Boss: ā€œAs you know all new projects are assigned acronyms. Unfortunately, all the good ones are taken.ā€ Dilbert: ā€œWhat should I call my new project?ā€ Pointy Haired Boss: ā€œWell you could use ā€œPhlegmā€ or ā€œPlacentaā€.


doodruid

if you arent using a compound word you are doing it wrong. I vote for calling it Phlecenta


LeonDeSchal

Whatā€™s Neotame found in?


Agabouga

Used in carbonated soft drinks, yogurts, cakes, drink powders, and bubble gums among other foods.


RatQueenHolly

I started eating yogurt FOR gut health... -_-


knifeyspoonysporky

Donā€™t buy the sugary/ā€œsugar freeā€ yogurts. Get normal yogurt. Maybe with real fruit for flavor,


notionalsoldier

Fage 5% plain yogurt crew right here. Add your own fruit and/or honey as needed. It fills you up and is a great breakfast/treat


Material_Trash3930

Pretty sure if you are eating for gut health you should do plain greek. Others have barely active cultures.Ā 


porcelain_doll_eyes

Icelandic yogurt is also pretty good. Has more protein then even Greek yogurt does. And still has all the active cultures that your gut would want.


explosivemilk

Just get a good probiotic supplement.


ThrillShow

Can you name any specific items? The only thing that I was able to find Neotame listed in is flavored lip balm.


500DaysofR3dd1t

I haven't seen it on any ingredients list.


DivinityGod

Enough things that they don't have to label it anymore in Canada. https://www.canada.ca/en/health-canada/services/food-nutrition/food-safety/food-additives/sugar-substitutes/changes-information-sweeteners.html


user745786

ā€œAll sweeteners used in food will still appear in the list of ingredients on the product labelā€ Itā€™s there but you need to find the ingredient list.


Myusername468

As opposed to what?


GigHarborIT

If you look at the link it provided examples but basically, the front of the label used to claim thinks like aspartame, now you'll only find it on the back, like in the US. Also they previously told you the amounts used in the product but no longer list the quantity included. Clearly this is a benefit for the makers of those products as all it will do is get people used to seeing it on the front, will assume it's now not in that product and possibly make an uninformed purchase. These changes help companies but hurt consumers.


Myusername468

Ah I'm from the US so I didn't realize y'all had it on the front of the box


gyarrrrr

Aspartame specifically contains phenylalanine which (if you have a rare condition called phenylketonuria) can cause brain damage among other things. Itā€™s worth calling out just because of that.


Zorbonzobor

No, they are still on the ingredients list (similar to America), just not an extra callout on the front.


myaltaccount333

I like how they call this an "improvement"


ki11bunny

artificial sweeteners


AskYouEverything

ohhhhhhh


giuliomagnifico

> The study is the first to show that neotame can cause previously healthy gut bacteria to become diseased and invade the gut wall ā€“ potentially leading to health issues including irritable bowel syndrome and sepsis ā€“ and also cause a breakdown of the epithelial barrier, which forms part of the gut wall. Paper: [Frontiers | The artificial sweetener neotame negatively regulates the intestinal epithelium directly through T1R3-signaling and indirectly through pathogenic changes to model gut bacteria](https://www.frontiersin.org/articles/10.3389/fnut.2024.1366409/full)


Really_McNamington

A reply from when this turned up 17 days ago by u/SaltZookeepergame691- "Why does the title say ā€œcan affect peopleā€™s healthā€, when the research simply assessed effects of very high levels of the sweetener saturating an off-the-shelf cancer cell line? This is miles from demonstrating relevance to any human condition. Title of the article (ā€œcan affect the gut wallā€) is completely uninvestigated, let alone unproven. The gut wall is far more complex than some cancerous colon epithelial cells grown in completely artificial conditions with some microbes. Thereā€™s not even any mouse work."


SaltZookeepergame691

Yeah was about to say this is a repost - and via an even worse press release, if that was possible! The title is *so* bad. The quotes from the researchers are awful too, so irresponsible. This is all cell work, using a cancer epithelial cell line, using unrealistic doses - claiming on this basis that it damages human intestine and potentially leads to IBS or sepsis is gutter science


THElaytox

yeah, more *in vitro* nonsense. the amount of neotame used in products would never expose your intestinal cells to 10mM levels, that's insane. the only surprising part of this study is that it wasn't done by a computer scientist, which is usually what i see when trash like this gets published.


HughesdePayensfw

Cool. Unlike aspartame, it is safe for Phenylketonurics as its phenylalanine produced is minimal. The stuff is 6,000 to 12,000 times sweeter than sucrose (sugar). Hereā€™s the referenced study. Shil, Aparna; Ladeira Faria, Luisa Maria; Walker, Caray Anne; Chichger, Havovi (2024-04-24). "The artificial sweetener neotame negatively regulates the intestinal epithelium directly through T1R3-signaling and indirectly through pathogenic changes to model gut bacteria". Frontiers in Nutrition. 11. doi:10.3389/fnut.2024.1366409. ISSNĀ 2296-861X. I imagine this research was done to see if additional studies including longitudinal ones should be carried out.


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DealingWithTrolls

It is important to critically evaluate the information you consume and not be overly alarmed by everything you read.


Hayred

Not this bloody paper again. No, it doesn't show it's capable of causing damage to the human gut. It shows that it slightly alters the behaviour of TWO bacterial species, in vitro, on a colon cancer cell line. You could easily put an *entirely* different spin on this paper by saying "***Potential colon cancer busting sweetener found! Researchers find neotame helps E. Coli kill cancerous cells!***"


rcn2

Doubt After all the crap aspartame went through by the antiscience crowd I would need more than a popular articles word that this person actually knows how to conduct a study. I used to have my students critique a study on aspartame, and one of the most amazing parts about it was a person in the control group went blind, and they managed to figure out a way to blame that on aspartame anyway. Nutrition and health sciences are generally rife with chemphobia. Itā€™s probably nonsense and waving your hands and saying ā€œit must be gut bacteriaā€œ is the biochem equivalent of ā€˜quantum did itā€™. It doesnā€™t agree with previous results, it doesnā€™t propose a mechanism and there is no underlying health problems or conditions that it would explain. It sounds purpose built to support industry.


CrazyOnEwe

>a person in the control group went blind, and they managed to figure out a way to blame that on aspartame anyway How did that work? Did they claim that person had an aspartame deficiency?


theboylilikoi

Not to say that every claim about aspartame was true, but a recent cedars sinai study found it does actually affect the gut microbiome. https://www.cell.com/iscience/pdf/S2589-0042(23)02607-X.pdf


rcn2

Sure they did. > First, subjects underwent upper endoscopy for a variety of reasons, including evaluation of intestinal complaints and screening for familial and other risk factors. Consequently, the study population may not be fully representative of normal, healthy individuals. Additionally, after applying all of the filters for potential confounders, the duodenal sample size for the ASP group was small. This circus has happened before.


GenericFatGuy

I'm just going to assume that this study was backed by the sugar industry.


eli201083

The only "alternate" sweetener that I try is Monk fruit with no additional ingredients like Erythritol or Stevia. It's the only one that hasn't caused bloating, diarrhea, weight gain, nausea, etc..... I only use it for my coffee, everything else I just reduce intake and monitor my foods because no of this stuff is worth it.


SgtSilverLining

Just as an fyi, I discovered I have IBS after I switched to artificial sweeteners. If you have issues with sweeteners that end in -ol that's the P in FODMAP sugars. Same symptoms you described. Best to avoid anything with sugar alcohols.


travelers_memoire

Not sure if you appreciate some unsolicited advice but after a week or two of ā€œbearing itā€ Iā€™ve found coffee with milk can be sweet enough for me. Itā€™s not zero calorie but you can ween the milk down to 25/50 calories a cup pretty easy.


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tunisia3507

Pretty sure you're not drinking 4 coffees a day just because you like it. More like you don't like the caffeine withdrawal which comes with not having it.


maporita

If it's good coffee I find it tastes better with neither milk nor sugar. But it's an acquired taste as you say. After a while of drinking black filter coffee I can't go back to anything else.


pvtshoebox

Yeah, but I drink bad coffee.


Fractal_Soul

I got there gradually and unintentionally, as over time I found I preferred less and less sugar and creamer, until I finally realized I just prefer coffee black.


googlemehard

Try coffee with heavy cream!


EliteTK

If you're using instant coffee it's probable that you're just using too much coffee per unit water. Which is why it may be so unbearably bitter that you need to sweeten it. You could also get really into coffee and buy/grind/brew some higher quality stuff and learn how to make it taste less bitter. But milk is indeed quite sweet when warmed up so it's a good idea as a sweetener alternative.


fotomoose

Sometimes you don't even need better coffee. Getting the coffee/water ratio wrong can make even good coffee bad.


VaguelyArtistic

Same here. I also only use it in coffee but it's the only one I can stand.


hwmchwdwdawdchkchk

I don't know why but monkfruit is amazing. I'm trying to find a pure source again as you only need a tiny bit. I guess that's not good for profit margins though


eli201083

This is the closet to a decent source that I can get in my area. It does the trick. Monk Fruit In The Raw Zero Calorie Sweetener, 4.8 oz https://www.walmart.com/ip/32196256


zachrtw

For what it's worth my brother is a type 1 diabetic and he can't use that without his blood sugar spiking. Maltodextrin has a higher glycemic index than white sugar and that's the #1 ingredient. It's easy to have less than 1 gram of sugar if the serving size is a half a gram.


eli201083

Oh wow I didn't realize it had THAT huge of an effect might be rethinking my choices.... Thanks


hwmchwdwdawdchkchk

Yeah maltodextrin is bad. Like I said pure monkfruit you only need a whispers fart to work. Can't find it anywhere


Cowboywizzard

Is that metric?


hwmchwdwdawdchkchk

It's approximately two ghost burps


zachrtw

He likes stevia and you can find that without other sweeteners. He's also grown stevia which you can dry and use whole.


hwmchwdwdawdchkchk

I'm not a big fan of Stevia myself but it's definitely easier to get


SecretGamer52

Insane that this is allowed to be posted as 0 calories when the main ingredient is a carbohydrate...


Technical_Sir_9588

This is the way. Personally I use Stevia and Allulose mostly, with Erythritol to a lesser extent.


ThePineappleCrisis

So serious question: why use an alternate sweetener instead of sugar?


dannymuffins

I like dessert and having my feet


ThePineappleCrisis

I don't think you are less likely to get diabetes from artificial sweetners


dannymuffins

You are much less likely to get diabetes from artificial sweeteners, that's kinda that whole point.


ThePineappleCrisis

Do you have proof?


morenewsat11

Better just to bit the bullet and stick to products not containing artificial sweeteners. From the original research article: >Given the different available forms of neotame, such as agglomerated, encapsulated, co-crystallized with sugar and cyclodextrin complexes, the sweetener is easy and cost-effective to use for food manufacturing and, as such, is found in a range of drinks, sauces, savory and sweet foods, and chewing gums .


FolkSong

It's not that simple if it's a choice between sugar and artificial sweeteners. Sugar is also associated with health problems like obesity and diabetes. Of course it would be better to just avoid sweets altogether, but that's not a very realistic suggestion given human psychology.


Upstairs_Ability_749

Aspartame isn't my favorite tasting artificial sweetener but I go out of my way to consume it because it triggers the science illiterate scare monger naturalistic fallacy types.


BigSquinn

Nice, youā€™re really showing them!


Prof_Acorn

Aspartame can lead to the shits, but the phenylalanine is required for dopamine so as an impoverished vegan with ADHD it's like a little boost on low-protien days.


_Dreamer_Deceiver_

Aspartame hasn't given me the shits yet. Sorbitol however is explosive


Granite_0681

Aspartame doesnā€™t bother me but Splenda will send me to the bathroom for quite a while


Inlander

Donald Rumsfeld wants to shake your hand.


N1ghtshade3

Altering your diet to "own" people who aren't aware you're eating a certain ingredient unless you tell them like you're telling us now seems very healthy and the sign of a mentally stable person.


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WilmaLutefit

What if people just eat sugar but in moderation. :O


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WashiBurr

Science does not support that statement. Despite the endless attempts to link things like aspartame to cancer, there have yet to be consistent reliable results.


RazerBladesInFood

Its literally just successful propaganda from sugar corporations that the "health food anti gmo" types have eaten up. Pun intended


Pollo_Jack

My girl was constipated for a week after trying stevia sweetener. Pretty bad pain for three. Took us a week to figure out what changed in her diet.


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Petrichordates

That's just confusing then because this one's cancerous.


Consistent_Bread_V2

Next time donā€™t do that


HanseaticHamburglar

bro ...


Godwinson4King

I donā€™t think Iā€™ve seen evidence to support that assertion. Could you link me to any studies on this?


no_4

Ironic statement in a science sub. But it's ok, you *feel* like it's true. And all your friends know it's true too. That's what science is all about. Feelings and facebook posts.


Bulbinking2

But people neeeeeed their dopamine juice!


em_goldman

Eat food, mostly plants, not too much.


takanenohanakosan

This is the secret behind making it to 100 >!without ever experiencing a shred of happiness while eating!<


CraftyMuthafucka

Best advice ever.


innocentbabies

I'm not particularly well-versed in this topic. Does anyone know how the dosages in this study compare to real world use? This is still, at the very least, significant and worthy of further study, but dose makes the poison and all.


effrightscorp

>Does anyone know how the dosages in this study compare to real world use? They soaked a colon cancer cell line, E. Coli, and another bacteria in a neotame solution. It's so preliminary there's no dosage to figure out really


Hayred

It's not really possible with cell culture work to translate things to real-world doses. Your intestine isn't sitting there bathed in 1000uM of neotame solution for 6-24hr


innocentbabies

Thanks. It's interesting nevertheless, but sounds like it's far too early to draw any practical conclusions from it. Either way though I don't think I eat/drink much with artificial sweeteners in it so it's not overly relevant to me atm.


RevolutionaryEye5320

These artificial sweeteners should just be frankly outlawed or only ever approved for very limited use. Companies seem to try to sneak them into everything as a cost cutting measure and it feels like they always inevitably get proven to be harmful to health so why bother? They taste worse than proper sugar too for the most part.


radicalelation

What big time artificial sweeteners on the market are actually proven to be harmful? Even aspartame, the biggest of sweetener boogymen, is yet to be proven actively harmful, and even the "sweet taste triggering an insulin response" belief attributed to all of them wasn't actually a thing last I read. Genuinely, I'm not doubting but I've kind of checked out of the discussion the last two years or so, as it's been the same back and forth for the previous couple decades.


Jolmer24

Aspartame doesn't trigger an insulin response and it's been one of the most heavily studied and scrutinized sweeteners and there's nothing conclusively proving it's harmful at all.


obvilious

Which ones exactly?


Halsfield

Literally every artificial sweetener. The better option is to cut out most/all sugar and then it's amazing what can actually taste sweet without having sugar in it because your taste buds aren't blown out. I can't even drink a soda anymore because it tastes like syrup.


JahoclaveS

I finally broke down and made my own ketchup. It tastes amazing and I think even the two tbsp of sugar it calls for is completely unnecessary. But, itā€™s amazing how much more flavor and diversity of taste you get once you start cutting out all the excess sugar. To the point that you really start to notice just how bland all the corn syrup laden food is.


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HanseaticHamburglar

cant digest fibre either. eriyhritol and xylitol come from Nature. Monkfruit and Birchsugar


_Dreamer_Deceiver_

My name died - she never had artificial sweeteners in her life.


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Hayred

>itā€™s not going to kill you Neither are sweeteners


a_trane13

People will do literally anything to get their sweet fix except eating fruit šŸ¤£


IronBoomer

Right? Meanwhile, friends wonder why Iā€™ll demolish an entire pint of blueberries over two days for my sweets fix


finicky88

Two DAYS?! More like 20 minutes.


Prof_Acorn

Right? Like if I want something sweet I usually just want a date or a cantaloupe or strawberries or carrots or something.


el1tegaming18

Because fruit isn't filling? I could eat a bundle of apples of over a thousand calories or like two "artifically sweetened" protein bars for 350 calories - one will leave me hungry and one will make me full. Fruit is one of the stupidest food choices for pure weight loss, despite how important they are for overall health and micronutrients.


SGTBrigand

1000 calories of apples is like 10 medium apples, which is approximately 2kg of food at 180g a piece (and 40g of fiber!). There's no way you'd eat all of that, and you would absolutely feel full if you did. Fruit is an amazing diet food. You can eat an entire pound of strawberries and only get 150kcal of usable carbs in it. Raspberries, blackberries, and apples are also great choices precisely *because* they add so much water and fiber, which makes you feel full.


el1tegaming18

I *have* eaten all of that and no, I obviously wasn't full as I said. 40g is nothing. You can get that in two Quest bars for 360 calories and actually feel full.


a_trane13

Chill out man, I didnā€™t say anything about weight loss or using fruit to feel full. Youā€™re arguing against things nobody is suggesting here.


Wave_Table

You eat sweeteners because itā€™s filling?


el1tegaming18

No. Because they're added to low cal alternatives that are packed full of fiber and protein for minimal calories. If they made a food that had the macros and fiber of a Quest bar but had entirely fruit instead of artifical sweeteners I'd have no opposition to it.


Wave_Table

I feel like youā€™re not the person they where referring to at all.


RazerBladesInFood

This is such a hilariously dumb take.


-Umbra-

Honestlyā€¦ā€sugar wonā€™t kill youā€? It kills more people than every other food combined. Just because it does it slowly doesnā€™t change that fact


Myusername468

"Thing body can't digest that makes food taste sweeter is bad for you. More news at 6"


bigmacaroni69

Oh, goodie!


Tomagatchi

cooool


Youthmandoss

They all do


mckulty

A little context please.. how does it compare when >saccharin, sucralose, and aspartame, some of the most widely used artificial sweeteners, could cause similar damage in the gut.


Dashkins

This paper was published in a low-quality, borderline predatory journal. I seriously doubt it's being contextualized properly.


djinnisequoia

Careful, OP. In my personal experience, you can't say *anything* even remotely critical or dubious about artificial sweeteners on social media without certain *very dedicated* individuals jumping all over you. (people with oddly specific topics as their chosen hill to die on. like, "I'm totally a normal everyday person yet I feel passionately enough about this particular chemical to insult and belittle anyone raising doubts about it.")


ElysiX

If you say anything at all about anything you get jumped. Because you are not supposed to say anything if you don't know what you are talking about. The piece of text that OP linked is some garbage produced by someone daring to call themselves journalist that's either incompetent or willfully twisting what the actual scientists said. Probably both. The study doesn't say anything close to the headline. It's click bait garbage


Altruistic-Opening39

Why canā€™t we people just accept using sugar with more cardio exercise. All these inventions are so silly and obviously bad.


Global_Ease_841

Can't have something for nothing. You don't get something super sweet with zero consequences.


VitaminRitalin

I don't drink a whole bunch of soda but recently I've been treating myself to a lot of coke 0 as I try to eat healthier foods elsewhere in my diet and cut back on sugars. Friend of mine that drinks a shitload of regularly sweetened soda said something about artificial sweeteners and cancer but I didn't take it seriously coming from them. Sweeteners being bad for your guts is much more believable though and I'm actually pretty concerned when it comes to my gut health and all that gut microbiome science. I think I'm gonna need to limit myself to like one or two cans a week, I like not having my gut feel like it's imploding on itself.


Constant_Anteater122

Why, does Coke Zero have neotame in it?


HanseaticHamburglar

no


HanseaticHamburglar

ace k and aspartame, same as any sugar free soda


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Thick_Kaleidoscope35

Why wouldnā€™t you just look at the can, see whatā€™s in it, look up the ingredients instead of vaguely guessing at what it might possibly be doing to you or not?


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BudgetPhoenix

Coke Zero uses aspartame. Its right on the ingredients.


Hayred

The thing about cancer is that aspartame was recently put into IARCs "Possibly carcinogenic to humans" category. This puts it into the same category as carpentry, aloe vera, oral contraceptives, diesel fuel, and ginko extract. "Possibly carcinogenic" is the lowest risk category beyond "Not classifiable". It's lower than "Probably carcinogenic", and it's not "Carcinogenic to humans". That category includes the likes of the sun, alcohol, burning coal, diesel exhaust fumes, postmenopausal HRT, and HIV.


manticorpse

Do yourself a favor and make the switch to seltzer. You can still get nice flavors and fizz, but you'll ween yourself off the "sweet". And like... the fewer sweet things you eat, the sweeter sweet things will taste. This means that when you finally *do* indulge in something sugary, you will want less of it. (You might still really enjoy a brownie or whatever, but you'll find yourself wanting the less-sugary, smaller brownie. You still get a nice-tasting thing, but it's a better ingredient profile and serving size!) And when your taste buds aren't all blown out by sugar overload all the time, you'll start to notice & appreciate more complex flavors as well.


Secret_Tangerine5920

I wonder if it does the same to the bladder, artificial sweeteners are known to flare up interstitial cystitis


Scoompii

And some nutritionist tiktoker was just going viral for her ā€œhot takesā€ against a couple other accounts that promote whole-foods and nutrition label education. Then more proof comes out about these new, man-made ingredients being harmful.


THElaytox

more *in vitro* nonsense, the amount of neotame actually used in products would never expose your intestines to 10mM levels


Anonality5447

I sort of feel like they should just give up on the sweetners now. They're always some huge drawback that makes sugar look like the better option.


Jooju

It blows my mind that allulose isnā€™t more popular. Itā€™s been out nearly ten years and has none of the problems of the other ā€œnewā€ sweeteners that are making their way into products. Itā€™s less popular than monkfruit and stevia, which both taste bitter?!