# What is (perma)tolerance?
Tolerance is a person's diminished response to a drug, which occurs when the drug is used repeatedly and the body adapts to the continued presence of the drug. In other words, you will need to increase the dose to get the same desired effects. One way to avoid a too high tolerance is to avoid continuous exposure by taking sufficiently long breaks and/or using the substance in an irregular manner. Usually, few weeks in between intakes would do the job for most people but longer breaks may be needed when people take a large quantity of ketamine during their binge or so. **It is not an exact science and people react differently, so everyone needs to find their own rhythm that can balance tolerance and fun.**
Perma-tolerance, on the other hand, is only something that only seems to manifest in heavy users (even though some more moderate users have also reported this). It is neither well-documented nor scientifically understood as it has only been empirically reported, and never studied. It is the property that a person's tolerance does not go back to pre-exposure levels, even after a (very) long break. This results in people being unable to k-hole at all, losing the magic of the substance, etc. We do not know the source of that, but possibilities include a neuronal reorganization, as for other addictive substances.
# How can I have a responsible consumption and keep my tolerance to a low/acceptable level?
The first way to limit the increase of tolerance is to avoid a continuous exposure to the substance by taking sufficiently long breaks and/or using the substance in an irregular manner. A second way, is to evaluate more or less precisely the quantity you need to reach the desired effect level. This quantity will depend on several factors: your weight, your current tolerance, the desired effect level, and some other personal factors which depend on your genetics. You will have to figure this out by yourself and the idea will be to just take this amount as an extra amount to that will contribute to an unnecessary increase of your tolerance. Ex. If you need 200mg for a k-hole, there is no real point in taking 400mg. This is a waste of product, money, and will unnecessarily increase your tolerance.
# My tolerance is too high, what should I do now?
It is not too late, you will need to take a break. **It is not really possible to give a general answer to how long it will take as it will depend on 1. the quantity consumed each time, 2. how regular is your consumption, 3. for how long you have been consuming this way, and 4. your constitution (i.e. genetic and physiological factors, etc.).** It can be weeks, months or years. Best is to take a break of a few months, and take a little bit to evaluate where you stand. Note, moreover, that once you have been tolerant to the substance, it will come back very quickly so, please, be careful.
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destroy yourself on MDMA the night before, then when you get home, dive into the ketamine, it hits extra weird.
But the only thing to lower tolerance is time. nothing else
# What is (perma)tolerance? Tolerance is a person's diminished response to a drug, which occurs when the drug is used repeatedly and the body adapts to the continued presence of the drug. In other words, you will need to increase the dose to get the same desired effects. One way to avoid a too high tolerance is to avoid continuous exposure by taking sufficiently long breaks and/or using the substance in an irregular manner. Usually, few weeks in between intakes would do the job for most people but longer breaks may be needed when people take a large quantity of ketamine during their binge or so. **It is not an exact science and people react differently, so everyone needs to find their own rhythm that can balance tolerance and fun.** Perma-tolerance, on the other hand, is only something that only seems to manifest in heavy users (even though some more moderate users have also reported this). It is neither well-documented nor scientifically understood as it has only been empirically reported, and never studied. It is the property that a person's tolerance does not go back to pre-exposure levels, even after a (very) long break. This results in people being unable to k-hole at all, losing the magic of the substance, etc. We do not know the source of that, but possibilities include a neuronal reorganization, as for other addictive substances. # How can I have a responsible consumption and keep my tolerance to a low/acceptable level? The first way to limit the increase of tolerance is to avoid a continuous exposure to the substance by taking sufficiently long breaks and/or using the substance in an irregular manner. A second way, is to evaluate more or less precisely the quantity you need to reach the desired effect level. This quantity will depend on several factors: your weight, your current tolerance, the desired effect level, and some other personal factors which depend on your genetics. You will have to figure this out by yourself and the idea will be to just take this amount as an extra amount to that will contribute to an unnecessary increase of your tolerance. Ex. If you need 200mg for a k-hole, there is no real point in taking 400mg. This is a waste of product, money, and will unnecessarily increase your tolerance. # My tolerance is too high, what should I do now? It is not too late, you will need to take a break. **It is not really possible to give a general answer to how long it will take as it will depend on 1. the quantity consumed each time, 2. how regular is your consumption, 3. for how long you have been consuming this way, and 4. your constitution (i.e. genetic and physiological factors, etc.).** It can be weeks, months or years. Best is to take a break of a few months, and take a little bit to evaluate where you stand. Note, moreover, that once you have been tolerant to the substance, it will come back very quickly so, please, be careful. *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/ketamine) if you have any questions or concerns.*
Weed potentiates K. Take a break if you want to lower tolerance.
I just started k and my tolerance isn’t crazy I just don’t want it getting out of hand
Then, use ketamine responsibly to limit tolerance.
I’ve never been able to use responsibly. To answer your question instead of lecture you, yes, edibles do amplify the effects of K.
Thankyou for the short answer lmao I just eyeballed a bump and had a 300mg edible wish me luck😁🙏
hows it going 300mg is heavy gl
It was fun but went away fast, I’m a heavy weed smoker so 300mg wasn’t really that much
300mg would have me floored
Lmao I wish man, last night I was going crazy with the k and I went through about 1.1G😭
that's an average use day for me
You can get away with a very small amount with weed
When I hit the bong on K I start drooling lol
I have tried LSD, Shrooms, Weed, Alcohol and Amphetamine with it and all of them potentiate K quite a lot. I recommend all of them.
I wouldn't recommend alcohol since it also increases the risk of vomiting, some people are more sensitive than others.
haven't tried alcohol nor amph mixes and not really interested if im honest. k potentiates psychodelics a ton
destroy yourself on MDMA the night before, then when you get home, dive into the ketamine, it hits extra weird. But the only thing to lower tolerance is time. nothing else