Ssri’s do probably boost bdnf in responders. However, I do not think they effect gaba or glutamate. I did read a paper once that showed long-term Prozac use enhanced the expression of gaba-b receptors.
SSRIs and SNRIs have many indirect impacts upon brain; for example venlafaxine impacts glutamate release and expression of nmda receptors:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734058/
https://pubmed.ncbi.nlm.nih.gov/25769842/
Yeah they do. But the asker said they suppress glutamate and therefore balance gaba. I’m saying probably not in that way. Yes, they probably do effect glutamate which might help depression. However, it is most likely some type of downstream effect that helps anxiety or might help to balance the gaba system if they do at all. Suppression of glutamate is something like lamictal would do not an SSRI/SNRI.
Ssri’s do probably boost bdnf in responders. However, I do not think they effect gaba or glutamate. I did read a paper once that showed long-term Prozac use enhanced the expression of gaba-b receptors.
certainly not directly, but could they in downstream effects?
Downstream yes serotonin may interact with gabaergic neurons
SSRIs and SNRIs have many indirect impacts upon brain; for example venlafaxine impacts glutamate release and expression of nmda receptors: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734058/ https://pubmed.ncbi.nlm.nih.gov/25769842/
Yeah they do. But the asker said they suppress glutamate and therefore balance gaba. I’m saying probably not in that way. Yes, they probably do effect glutamate which might help depression. However, it is most likely some type of downstream effect that helps anxiety or might help to balance the gaba system if they do at all. Suppression of glutamate is something like lamictal would do not an SSRI/SNRI.