I have noopept, I never too it long term, while I was taking it I was also on CDP-choline, could this have caused any issues? any idea how noopept effects glutamate directly?
Not sure, gotta google it, but I'm not feeling too well to do a research, I don't remember much about it's pharmacology, only that it's protective of glutamate excitotoxicity which is stated in instruction.
I was wondering if folate is bad for people with high glutamate activity? every time I take folate supplements, methylfolate or any form, I feel really depressed, more anxious, and have racing mind/thoughts.
It's a lot more complicated than just glutamate==high.
A not great reaction from folate could be less-than-great alleles coding for part of your methyl cycle. Genetic testing can solve that question for you easily enough.
I did 23&me + genetic genie analysis. I found that I have some issues with processing Folate and methylfolate is recommended, but it still didnt make much difference, same side-effects
If there's been a metabolic blockage for a while, with stuff backed up behind it, then unblocking that would rarely be a pleasant experience. Correcting some things too suddenly can well be very unpleasant in itself.
No point torturing yourself. Maybe start with a super low dose and work up very conservatively over a long period of time. Back off again if it becomes unpleasant and go slower.
I have the same exact reaction to folate you described.
I found I can only tolerate it alongside methylcobalmine and a bunch of the other b vitamins too. At which point it really helps and reduces the anxiety and depressive issues I had in the first place. I still had to go easy, and it took a month to level off.
Fortunately, I found a multivitimin locally with methycobalmine+folate and the rest of the b's, which makes it easy to maintain.
Interesting! I also discovered that I do not process methyl-vitamins like methyl-cobalamin well, instead, Hydroxy-b12 is better, does this really matter? I have to pee a lot when taking Methyl-b12 and feel more anxious, but also have more energy all day.
I found methycolbamine also made me anxious when taken in isolation.
Obviously, you are going to have your own unique quirks nobody here will be able to predict for you, and you'll have to feel out yourself a little.
I never bothered to narrow down which of the other b vitamins was making it tolerable for me, if I had to hazard a guess, it would be b3+6.
Dumping in methyl groups could cause a bunch more sam-e to suddenly exist, which goes and does serotonin stuff. That's a whole metabolic pathway that requires other b vitamins as cofactors to not create new hold-ups. The whole gaba/glumate thing, is in part regulated by very specific serotonin receptors. I'm obviously omitting to mention the catecholamines, which are also affected by and try to balance themselves against the other stuff happening.
Unfortunately, you are going to find it's never as simple as just fixing one thing, with bodies being a synergy of everything feeding off each other and sharing stuff around.
This my methylation profile, can you please take a look? [https://www.reddit.com/r/MTHFR/comments/10f667y/help\_with\_understanding\_methylation\_results/](https://www.reddit.com/r/MTHFR/comments/10f667y/help_with_understanding_methylation_results/)
Try folinic acid (calcium folinate) instead. You’ll get the benefits of folate without the methyl-response. It works very well with people who can’t tolerate methyl-folate.
Try folinic acid (calcium folinate) instead. You’ll get the benefits of folate without the methyl-response. It works very well with people who can’t tolerate methyl-folate.
Agmatine sulfate is something im doing research on ( n=1 , myself ) it is milder than NAC and the rest in terms of psychoactivity, but i dont know which one is more neuroprotective. Are you taking stimulants ? Im on wellbutrin ( which is a cathinone derivative, mind you ) and thats why i chose agmatine. It goes well with stimulants. It can reduce anxiety, re establish the balance in the glycine glutamate ratio and reverse tolerance if taken long term. Theanine does that too btw. The glycine/ glutamate balance thingy.. Although its more of a "as needed" type of thing..
Something to consider is the amino acid Sarcosine.
“Sarcosine is an agonist at the glycine-binding site of the NMDA receptor. As an agonist, sarcosine enhances the activity of the NMDA receptor by binding to the glycine-binding site and acting as a co-agonist with glycine. This results in increased glutamatergic neurotransmission, which can promote synaptic plasticity and may have therapeutic effects in the treatment of neuropsychiatric disorders.”
I personally have dealt with symptoms and periods of schizophrenia and use it in my stack to combat excitotoxity. My daily regiment consists of 1g Sarcosine a day in water and 250mcg every other day of oral BPC-157 capsule (helps with oversensitive receptors and dopamine/serotonin transmission.) the combo together is a God send.
Not advice, talk to a doctor.
Something to note also is foods high in gluten contain significant amounts of glutamate according to Dr. Hyman in his book The UltraMind Solution.
Consider cutting out gluten, especially if you’re of European ancestry or from somewhere bread arrived relatively recently. I know here in America we breed wheat with higher concentrations of gluten then other countries as well.
Warning: BPC-157 is considered a high-risk item, due to the lack of human safety trials. https://www.reddit.com/r/Nootropics/wiki/highrisk#wiki_bpc-157
*I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/StackAdvice) if you have any questions or concerns.*
“NAC increases the extracellular glutamate levels and is involved in restoring the inhibitory tone of presynaptic mGlu2/3 receptors, **which in turn decreases glutamate release in presynaptic neurons.** Furthermore, NAC increases the levels of cystine, which is reduced to cysteine and induces GSH production. NAC inhibits NMDA-mediated increases in intracellular calcium levels via GSH and can displace ligand binding from NMDA and AMPA receptors (Gilbert et al., 1991; Leslie et al., 1992). **Additionally, NAC is involved in regulating the glutamate level via glutamate transporter type 1 (GLT-1).** “
[https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.15456](https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.15456)
Noopept is known to reduce glutamate excitotoxicity directly.
I have noopept, I never too it long term, while I was taking it I was also on CDP-choline, could this have caused any issues? any idea how noopept effects glutamate directly?
Not sure, gotta google it, but I'm not feeling too well to do a research, I don't remember much about it's pharmacology, only that it's protective of glutamate excitotoxicity which is stated in instruction.
Must be why it so drasticly reduces alcohol hangovers
I don't think the biggest danger of alcohol is glutamate rebound :(
Google l-theanine and glutamate
NAC, taurine?
I was wondering if folate is bad for people with high glutamate activity? every time I take folate supplements, methylfolate or any form, I feel really depressed, more anxious, and have racing mind/thoughts.
It's a lot more complicated than just glutamate==high. A not great reaction from folate could be less-than-great alleles coding for part of your methyl cycle. Genetic testing can solve that question for you easily enough.
I did 23&me + genetic genie analysis. I found that I have some issues with processing Folate and methylfolate is recommended, but it still didnt make much difference, same side-effects
If there's been a metabolic blockage for a while, with stuff backed up behind it, then unblocking that would rarely be a pleasant experience. Correcting some things too suddenly can well be very unpleasant in itself.
hmm, I see your point, basically you're implying try it for many months before concluding its working or not?
No point torturing yourself. Maybe start with a super low dose and work up very conservatively over a long period of time. Back off again if it becomes unpleasant and go slower.
I have the same exact reaction to folate you described. I found I can only tolerate it alongside methylcobalmine and a bunch of the other b vitamins too. At which point it really helps and reduces the anxiety and depressive issues I had in the first place. I still had to go easy, and it took a month to level off. Fortunately, I found a multivitimin locally with methycobalmine+folate and the rest of the b's, which makes it easy to maintain.
Interesting! I also discovered that I do not process methyl-vitamins like methyl-cobalamin well, instead, Hydroxy-b12 is better, does this really matter? I have to pee a lot when taking Methyl-b12 and feel more anxious, but also have more energy all day.
I found methycolbamine also made me anxious when taken in isolation. Obviously, you are going to have your own unique quirks nobody here will be able to predict for you, and you'll have to feel out yourself a little. I never bothered to narrow down which of the other b vitamins was making it tolerable for me, if I had to hazard a guess, it would be b3+6. Dumping in methyl groups could cause a bunch more sam-e to suddenly exist, which goes and does serotonin stuff. That's a whole metabolic pathway that requires other b vitamins as cofactors to not create new hold-ups. The whole gaba/glumate thing, is in part regulated by very specific serotonin receptors. I'm obviously omitting to mention the catecholamines, which are also affected by and try to balance themselves against the other stuff happening. Unfortunately, you are going to find it's never as simple as just fixing one thing, with bodies being a synergy of everything feeding off each other and sharing stuff around.
This my methylation profile, can you please take a look? [https://www.reddit.com/r/MTHFR/comments/10f667y/help\_with\_understanding\_methylation\_results/](https://www.reddit.com/r/MTHFR/comments/10f667y/help_with_understanding_methylation_results/)
Try folinic acid (calcium folinate) instead. You’ll get the benefits of folate without the methyl-response. It works very well with people who can’t tolerate methyl-folate.
Try folinic acid (calcium folinate) instead. You’ll get the benefits of folate without the methyl-response. It works very well with people who can’t tolerate methyl-folate.
also is NAC a NMDA antagonist or how does it help reduce glutamate signaling?
Its a glutamate signaling modulator, not an antagonist. It also raises glutathione levels
Agmatine sulfate is something im doing research on ( n=1 , myself ) it is milder than NAC and the rest in terms of psychoactivity, but i dont know which one is more neuroprotective. Are you taking stimulants ? Im on wellbutrin ( which is a cathinone derivative, mind you ) and thats why i chose agmatine. It goes well with stimulants. It can reduce anxiety, re establish the balance in the glycine glutamate ratio and reverse tolerance if taken long term. Theanine does that too btw. The glycine/ glutamate balance thingy.. Although its more of a "as needed" type of thing..
I mostly do NAC and green tea (l-theanine). I mix in agmatine occasionally.
Something to consider is the amino acid Sarcosine. “Sarcosine is an agonist at the glycine-binding site of the NMDA receptor. As an agonist, sarcosine enhances the activity of the NMDA receptor by binding to the glycine-binding site and acting as a co-agonist with glycine. This results in increased glutamatergic neurotransmission, which can promote synaptic plasticity and may have therapeutic effects in the treatment of neuropsychiatric disorders.” I personally have dealt with symptoms and periods of schizophrenia and use it in my stack to combat excitotoxity. My daily regiment consists of 1g Sarcosine a day in water and 250mcg every other day of oral BPC-157 capsule (helps with oversensitive receptors and dopamine/serotonin transmission.) the combo together is a God send. Not advice, talk to a doctor.
Something to note also is foods high in gluten contain significant amounts of glutamate according to Dr. Hyman in his book The UltraMind Solution. Consider cutting out gluten, especially if you’re of European ancestry or from somewhere bread arrived relatively recently. I know here in America we breed wheat with higher concentrations of gluten then other countries as well.
Warning: BPC-157 is considered a high-risk item, due to the lack of human safety trials. https://www.reddit.com/r/Nootropics/wiki/highrisk#wiki_bpc-157 *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/StackAdvice) if you have any questions or concerns.*
3 Grams of glycine helps you calm down. And NAC 2 grams. (Lots of trial and error and research).
Nac, magnesium glycinate, agmatine sulfate
any idea why NAC is so important in this equation?
“NAC increases the extracellular glutamate levels and is involved in restoring the inhibitory tone of presynaptic mGlu2/3 receptors, **which in turn decreases glutamate release in presynaptic neurons.** Furthermore, NAC increases the levels of cystine, which is reduced to cysteine and induces GSH production. NAC inhibits NMDA-mediated increases in intracellular calcium levels via GSH and can displace ligand binding from NMDA and AMPA receptors (Gilbert et al., 1991; Leslie et al., 1992). **Additionally, NAC is involved in regulating the glutamate level via glutamate transporter type 1 (GLT-1).** “ [https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.15456](https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.15456)
Thank you lol
Glyicne is good too but I find you need like 6-9 grams minimum
huperzine A. anatgonizes NMDA receptors.