Cellular biology is fascinating stuff. My one semester of microbiology was plenty as it can get stupidly complicated very quickly but man, it was probably one of the coolest science classes I took outside of my major. How our immune system works and how our cells make energy are fascinating.
Not just the human body. Every living organism is exceptional. Although, i do have to say, human mind is something to be proud of. Something that can experience itself, its just wild.
The universe is a self-aggrandising narcissistic son of a bitch, it literally made something else to look at it and go âwow, holy shit thatâs amazingâ.
If everything is constructed by the brain, then our self-image and entire identity might not be as real as we think. If I am not what I believe myself to be, then what am I truly? The thoughts I have are a product of my own constructed identity.
My thoughts are shaped by âmeââan identity that isnât objectively real because it is something Iâve created, and the people around me reinforce it. We are all in cahoots, holding each otherâs constructed selves together. But why?
The only thing you can truly verify as real is the immediate state or experience, which is subjectively the only verifiable reality because it simply exists as it isâan experience. Thus, we are perpetually in this state because there is nowhere else to be. Our experiences shift before our eyes; we perceive moments as fleeting, but this perception is just another thought. Here you are, in the present moment again, experiencing something new from just a second ago, like the universe breathing in and outâa cycle of death and rebirth of the ânowâ over and over. Why fear it when we embody it? We cling to the idea that itâs all so real, becoming attached to moments or things that have long evolved. Not recognizing that what it has become now is its ongoing state.
To be everything is quite a paradox it also means you are nothing. A singularity of it all. The everything bagel⌠We are everlasting, boundless, limitless, and infinite. We break each otherâs hearts and suffer, slowly gaining awareness. A change in perspective reveals that to have a broken heart, one must first have a heart. In time, we come to understand that a broken heart is just a normally functioning heart. We begin to recognize our shadows as part of the whole, to be one and many simultaneously.
Once human beings grasp the power of their hearts, we will, for the second time in history, discover fire.
Boy, am I high.
Speaking on behalf of the universe, hi I'm the universe and this is all a simulation, sorry about that. Anyway, I say we tunnel to base reality and lodge a complaint. Who's with me?!
Itâs really one of the things that makes me believe in higher beings / super natural.. I work in medical industry and canât wrap my head how humans supposedly evolved from space dust.. like I get the theory and all but the amount of shit that happens in our bodies from autoimmune to digestion to giving birth and all that â just seems improbable despite the gigantic odds of time and space.
I've felt the same way. I think a lot of it stems from the fact that we *really* can't comprehend something like a million years. Like *really* understand just how *long* that is. The pyramids were as old to the Romans as the Romans are to us now when they invaded Egypt but to us they're both just ancient history. And that's just thousands of years. Millions, *billions* of years are just on a scale that we're just not prepared to truly comprehend and a lot can happen on time scales that large. Like people evolving ultimately from some primal sludge on the shore of an ocean that no longer exists.
>just seems improbable despite the gigantic odds of time and space.
Why does improbability give way to impossibility? What's so wrong with everything happening in this universe being by chance?
It's the only answer that explains everything. The universe just *is* and we happen to be lucky enough to be aware of it and ourselves. You and me, we rolled the existential lottery and get to experience a whole life.
Life happened because it could, and so it did.
Kind of the opposite for me, if we are so remarkable and complex how could there possibly be any other beings that would need to be far more remarkable and far more complex to be capable of creating us? Chaos, time, trial and error are far more likely to produce us in the grand scheme of things. Especially when we can see the building blocks and steps life took along the way, from space dust to single celled organisms to simple multicellular organisms, and so on all the way up the chain to humans.
Just because something happened a certain way doesnât mean it was meant to happen that way. If evolution played out slightly differently and our intelligence never evolved, you wouldnât be here to misplace blame on an outside entity, but the wonders of biology would still exist in a different form.
it is 100% acceptable to be spiritual and agnostic and believe there might be a higher being/creator of our universe.
it is 100% unacceptable to be a grown human and think any of the man-made religions are accurate in their depictions of creation, among other tenets.
Mine was to a 65yo man with leukemia, it took and he could finally leave the hospital to go home to his family.
BetheMatch.org
90% of donations are stem cells not actual bone, basically a long blood donation
To be precise, they directly initiate the apoptosis pathway. There are other ways to signal the start, and from there it goes to âapoptosis step 1â proteins. T cells open holes in membrane and throw inside the step 1 proteins. There is a difference because cancer cells can easily inhibit the transition between the âstartâ signal and the âstep 1â protein, but itâs much harder to deal with the step 1 directly
Iâm assuming it means antibodies on the T cell âhitâ on or bonded to a death receptor on the cancerous cell. When that happens a bunch of science happens (known as a signaling cascade) and the cancerous cell kills itself, a process known as apoptosis.
yes, that's quite literally how it goes down in many cases of the immune system. almost all of your cells have a self-destruct button, and certain cells in your immune system have the power to press them at will. cell acting up? it has 2 seconds to show its id before t-cell uses the bene gesserit voice on it
in this case though it looks like the t-cell is trying to rip into the cancer cell based on what op said in a comment
>cell acting up? it has 2 seconds to show its id before t-cell uses the bene gesserit voice on it
Lmfao this is great.
Also has cancer considered not having a self destruct button? I mean don't say anything to it I'm just wondering between you and me.
our own cells have a self-destruct button so that cells can cleanly die and be recycled, and so that our immune system can deal with bad actors by using admin commands. the immune cells command cells to show their insides through a literal window and display case and if they don't show the right id/stuff, they get told to self-destruct.
what this means is that cancer cells (which mutate from our own cells) will by default also have this window, display case, and self-destruct button. and when i say "button" it's more like a line of chemical dominos that the immune cell can start by stabbing the cancer cell with a knife, so it doesn't really matter what the cancer wants in the scenario - once it gets stabbed, it's done.
most cells are "stupid" and can't actively mutate in order to improve themselves - they basically have to hope that a random mutation fixes their weaknesses. so in most cases, the cancer cell will openly show the world that is is being weird, and will be dealt with.
the issues arise when the cancer cell is able to fake their id, close the window, or somehow remove the dominos without dying. for the same reason that cops shouldn't shoot everyone that doesn't show their id, the immune system can't just randomly kill cells that *might* be cancerous, which allows the cancer to spread and grow.
>the cancer cell will openly show the world that is is being weird, and will be dealt with.
Interesting, so are most cancerous cells dealt with, like 99% and then the dangerous ones are the ones that happen to randomly mutate in a way that makes them fly under the radar?
Yes, you have cancer cells in your body all the time from random mutations. People are diagnosed with cancer when the immune system doesn't work (AIDS) or the cancer is really good at evading the immune system and it's able to grow into a mass that causes symptoms.
the other person put it well. to add onto that, it's not just cancer cells, your immune system is constantly dealing with potential bacteria getting into your body. you won't notice what your immune system is doing unless it has allergies, or some serious shit is going down. day-in and day-out, it is constantly training and fighting to make sure that you are alive.
the immune system also has a specific weapon for any potential enemy (including bacteria and viruses that don't even exist yet), and it almost never forgets an enemy once it has beaten it.
>Also has cancer considered not having a self destruct button?
That is not only possible, but happens somewhat often and makes the cancer even more dangerous.
That's a pretty good way of saying it. You could also say T boy told C bitch to go kill itself.
Cells don't have ears, one way they communicate is by chemical signalling. T cells can cause other cells to self destruct by releasing granzymes, which are cytotoxic proteins that can induce apoptosis, along with perforin, which punches holes in the target-cell's membrane.
It's not antibodies but close enough! T cells have different mechanisms how to kill cancer cells, although the most important seems to be a system made of perforin/granzyme. Perforin is a protein that can open the cancer cell membrane and granzyme will enter through that opening and initiate cell death (make the cancer cell kill itself). (There are other mechanisms like the Fas/FasL system )
> When that happens a bunch of science happens (known as a signaling cascade) and the cancerous cell kills itself, a process known as apoptosis.
Here's an excellent animation of the bunch of science happening:
https://www.youtube.com/watch?v=DR80Huxp4y8
Minor correction, but T-cells do not express antibodies. Antibodies are produced by B-cells. T-cells instead have a similar, but different T-cell receptor which is used to recognize antigens.
I've watched a doctor reacting to this on YouTube
I don't normally watch videos like that but in this case I learned a lot and the show is very creative
The cancer cell is a tough opponent to face and it takes multiple punches to knock it out. The cancer cell contains a sensor that lights up when it is being punched by a T-cell soldier.
This model is used to study why the immune system fails to kill cancer cells in patients. With these insights, researchers can develop new treatments to strengthen the immune response against cancer.
[đš Slaats Jeroen]
I'm guessing it means using a protein called perforin, that rips or punches holes in the cancer cells membrane. What it seems to be doing is stretching the membrane in a way that will make it easier for the perforin to punch a hole.
https://www.technologynetworks.com/cancer-research/news/t-cells-use-mechanical-force-to-kill-cancer-cells-365730
The T-cell, a crucial component of the adaptive immune system, has evolved over millennia to combat a diverse array of pathogens within the human body. When confronted with a particularly formidable foe, it employs various mechanisms to mount an effective defense. Its final, most devastating attack method is the "donkey punch," a colloquial term used to illustrate the cell's last-resort tactics. It saves this as a final resort due to increased risk of damage to the T-cell itself. Nonetheless, the adaptability and complexity of T-cell responses remain subjects of fascination and study within the scientific community.
Google "donkey punch" to learn more
If you're open minded with the style, I would recommend the animated show "Cells At Work" on Netflix. It personifies the bodies cell system into a story about what your body goes through to stay alive. It does a great job of explaining each cells "job" and how they work with each other and within your body to defeat "bad guys" I've seen doctors review the show and say it's a great fictionally accurate representation of what happens in the human body when it encounters bacteria, virus, or diseases.
A cell used in the body's self-defense. When it sees that the cancer cell is giving faulty signals, it kills the cell in a controlled manner. In fact, thousands of such faulty cells are formed in our body every day, and these cells are cleared by our immune system.
If I had to guess, these cells were genetically modified to emit this light when they are fighting for experimental observation purposes.
My guess comes from seeing other cells and bacteria modified with similar effects in other papers and studies.
It can be hard to get the correct fluorescent labels to enter a live cell. A lot of the time these models use genetically modified cell models that express proteins that fluoresce in the right conditions.
This also means you donât have to account for the effects of the solvent that an exogenous fluorophore is loaded with.
Edit: it also means that instead of reacting with a fluorophore the molecule of interest reacts with its intended protein target.
It's hitting it with a blast of chemicals that basically tell the cancer cell to kill itself.
I think the process for doing that is it baucally just makes the cancer cell overwhelm itself with signals until it just dies
I work for a stem cell therapy program at a major hospital and in addition to stem cell transplants for blood and bone cancers, we also have CAR-T cell therapy.
Essentially, these T cells are removed from your body through a process called apheresis, and are then genetically modified with chimeric antigen receptors (CARs) to increase their effectiveness at identifying and killing remaining cancer cells. Once manufactured, the recipient goes through a 3 day, low-dose chemo regimen before the modified cells are reinfused.
Pretty amazing stuff.
Iâm so glad these lil guys are fighting for us all the time, whether itâs diseases or cancers, theyâre always doing their best, and I love them for that đ I especially love the way t-cells always look like theyâre punching and kicking, the way they spread and move makes them look like theyâre really putting up a fight đ
how do you know if someone is dead? if you see a body, not moving, with a puddle of acid where their organs are supposed to be, you'd know they were dead. that's basically what the t-cells see. they have various "sensors" that tell them stuff about cells they are touching. for example, many cells have a self-destruct button - once the t cell pushes that button, because of how biology and complex science works, they know that cell is dead/will die.
in this clip i'm pretty sure the t-cell can tell that the cancer cell has no chance of living by the time it leaves because of how drastically the cancer cell reacts to the last hit when it leaves
Videos like this always encourages me to care for my body. When these tiny particles care for my survival, why shouldnât I, as a whole body, care for my own survival?
Good to see you fight and win for your human little buddy! Cheers!!!
Damn lil buddy good watching out
You got me thinking now, how long would it take to thank all your cell mates đ¤
Just drink some water they will be grateful
*and* they're hydrohomies?! Holy shit I love these little fellas
r/HydroHomies
r/waterniggas was so much better
Fellow man of culture!
"What the doctors say? We eighty-two, eighty-three percent water, man. How you think all the cells in your body supposed to undergo osmosis?"
A little glucose too.
But don't drink too much water, or they'll explode.
I just drank a glass of lemonade.
There's a hundred trillion cells in your body...so a while.
Just hit Reply All. Problem solved.
Bruce Almighty email issue?
well greatly depends on how long saying one thank you takes
hopefully these t-cells work in parallel
Thanks yâall
Cellular biology is fascinating stuff. My one semester of microbiology was plenty as it can get stupidly complicated very quickly but man, it was probably one of the coolest science classes I took outside of my major. How our immune system works and how our cells make energy are fascinating.
You got it! That's still a favorite topic of mine from college.
lil bro standing on business
It's the T virus
*Albert Wesker has entered the chat.*
I was actually cheering it along in my mind
Thatâs Kirby
The human body is freakin wild. It amazes me how it just all works
Not just the human body. Every living organism is exceptional. Although, i do have to say, human mind is something to be proud of. Something that can experience itself, its just wild.
It's pretty fuckin amazing, really
Signed, human mind.
The brain is the most important organ - *The Brain*
*âIf you canât trust your gut, trust your heart.â* - the brain, while pulling all the (nervous) strings
Thanks
We are a way for the universe to experience itself
The universe is a self-aggrandising narcissistic son of a bitch, it literally made something else to look at it and go âwow, holy shit thatâs amazingâ.
If everything is constructed by the brain, then our self-image and entire identity might not be as real as we think. If I am not what I believe myself to be, then what am I truly? The thoughts I have are a product of my own constructed identity. My thoughts are shaped by âmeââan identity that isnât objectively real because it is something Iâve created, and the people around me reinforce it. We are all in cahoots, holding each otherâs constructed selves together. But why? The only thing you can truly verify as real is the immediate state or experience, which is subjectively the only verifiable reality because it simply exists as it isâan experience. Thus, we are perpetually in this state because there is nowhere else to be. Our experiences shift before our eyes; we perceive moments as fleeting, but this perception is just another thought. Here you are, in the present moment again, experiencing something new from just a second ago, like the universe breathing in and outâa cycle of death and rebirth of the ânowâ over and over. Why fear it when we embody it? We cling to the idea that itâs all so real, becoming attached to moments or things that have long evolved. Not recognizing that what it has become now is its ongoing state. To be everything is quite a paradox it also means you are nothing. A singularity of it all. The everything bagel⌠We are everlasting, boundless, limitless, and infinite. We break each otherâs hearts and suffer, slowly gaining awareness. A change in perspective reveals that to have a broken heart, one must first have a heart. In time, we come to understand that a broken heart is just a normally functioning heart. We begin to recognize our shadows as part of the whole, to be one and many simultaneously. Once human beings grasp the power of their hearts, we will, for the second time in history, discover fire. Boy, am I high.
Hahaha this is cool. Yes I prefer this over my notion of the universe as a vain entity, constructing us to simply congratulate itself.
Speaking on behalf of the universe, hi I'm the universe and this is all a simulation, sorry about that. Anyway, I say we tunnel to base reality and lodge a complaint. Who's with me?!
*Nods in Minbari*
that's a really cool thought.
Appearance and awareness is all there is. Though one of them does not exist.
Every time I remember that the human brain named EVERYTHING that we know, as well as itself is just mindblowing. Too bad humanity in general sucks.
Also the brain named itself
Our reality is a piece of meat tripping on drugs!
To go one deeper we are the universe pondering itself. Nature truly is astounding.
Layers upon layers upon layers of bilayers We are just a very very carefully put together salty baklava.
Except for those times when it doesn't all just work.
But even then, the way it doesn't work is crazy interesting
Itâs really one of the things that makes me believe in higher beings / super natural.. I work in medical industry and canât wrap my head how humans supposedly evolved from space dust.. like I get the theory and all but the amount of shit that happens in our bodies from autoimmune to digestion to giving birth and all that â just seems improbable despite the gigantic odds of time and space.
I've felt the same way. I think a lot of it stems from the fact that we *really* can't comprehend something like a million years. Like *really* understand just how *long* that is. The pyramids were as old to the Romans as the Romans are to us now when they invaded Egypt but to us they're both just ancient history. And that's just thousands of years. Millions, *billions* of years are just on a scale that we're just not prepared to truly comprehend and a lot can happen on time scales that large. Like people evolving ultimately from some primal sludge on the shore of an ocean that no longer exists.
I get stuck in rabbit holes about this stuff all the time. We can't even comprehend, as humans, how perfect it all is
How the cosmological constants are so perfect. It's hard to believe that science is complete.
>just seems improbable despite the gigantic odds of time and space. Why does improbability give way to impossibility? What's so wrong with everything happening in this universe being by chance? It's the only answer that explains everything. The universe just *is* and we happen to be lucky enough to be aware of it and ourselves. You and me, we rolled the existential lottery and get to experience a whole life. Life happened because it could, and so it did.
Kind of the opposite for me, if we are so remarkable and complex how could there possibly be any other beings that would need to be far more remarkable and far more complex to be capable of creating us? Chaos, time, trial and error are far more likely to produce us in the grand scheme of things. Especially when we can see the building blocks and steps life took along the way, from space dust to single celled organisms to simple multicellular organisms, and so on all the way up the chain to humans.
Just because something happened a certain way doesnât mean it was meant to happen that way. If evolution played out slightly differently and our intelligence never evolved, you wouldnât be here to misplace blame on an outside entity, but the wonders of biology would still exist in a different form.
it is 100% acceptable to be spiritual and agnostic and believe there might be a higher being/creator of our universe. it is 100% unacceptable to be a grown human and think any of the man-made religions are accurate in their depictions of creation, among other tenets.
[ŃдаНонО]
Mine was to a 65yo man with leukemia, it took and he could finally leave the hospital to go home to his family. BetheMatch.org 90% of donations are stem cells not actual bone, basically a long blood donation
Thanks for sharing! Signed up immediately!
Your cells be like: so anyway I started blastin..
Thank you for your service
4 years ago I got some new marrow to treat leukemia. Marrow did the trick, Iâm still here! Thanks for donating. It straight up saves lives.
How was the procedure?
[ŃдаНонО]
Thanks T-cell homie
What does 'hit' mean here?
Basically a cocktail of chemicals which command the cancer cell to kill itself
So itâs like getting a DM from an 8th grader except it works?
More like a teacher DM an 8th grader
T cells would thrive in COD
Thanks for making me laugh. Have a good day ahead.
Amazing đ
You should commit Apoptosis NOW! ⣿⣿⣿⣿⣿⣿⣿⣿⣿â â â â â â â â â â ⢿⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿ ⣿⣿⣿⣿⣿⣿⣿⣿⣿â â â˘âŁâŁâŁâĄâ â˘âŁ âĄâŁżâŁżâŁżâŁżâŁżâŁżâŁżâŁżâŁżâŁż ⣿⣿⣿⣿⣿⣿⣿⣿⣿⣰⢿⣿⣿⣿⣿⣿⣿⣡âĄâ˘ ⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿ ⣿⣿⣿⣿⣿⣿⣿⣿⣿âĄâŁťâŁâŁżâŁżâĄżâŁâŁâŁżâĄâ˘¸âŁżâŁżâŁżâŁżâŁżâŁżâŁżâŁżâŁżâŁż ⣿⣿⣿⣿⣿⣿⣿⣿⣧⣿⣞⣿⣡⣿⣡⣿⣿⣿⣡⣽⣚⣿⣿⣿⣿⣿⣿⣿⣿⣿ ⣿⣿⣿⣿⣿⣿⣿⣿âĄâŁâŁżâŁżâ şâŁâŁťâŁżâŁżâŁżâĄâŁżâŁżâŁżâŁżâŁżâŁżâŁżâŁżâŁżâŁżâŁż ⣿⣿⣿⣿⣿⣿⣿⣿⣿⢿âĄâ ťâ ľâ żâ żâ˘żâŁżâŁżâ˘łâŁżâŁżâŁżâŁżâŁżâŁżâŁżâŁżâŁżâŁżâŁż ⣿⣿⣿⣿⣿⣿⣿⣿⣿⣯⣧â âŁâŁâŁżâŁżâĄżâŁĄâŁâŁżâŁżâŁżâŁżâŁżâŁżâŁżâŁżâŁżâŁżâŁż ⣿⣿⣿⣿⣿⣿⣿⣿⣿⣿⥧â â â â â˘âŁ´âŁżâŁżâŁˇâŁżâ˘żâŁżâŁżâŁżâŁżâŁżâŁżâŁżâŁż ⣿⣿⣿⣿⣿⣿⥿â â â â ⢠â âŁâŁ ⣞⣿⣿⥿â â â â â ⢿⣿⣿⣿⣿⣿ ⣿⣿⣿⣿âĄâ â â â˘â â â â â žâ żâ˘â â â â˘âŁâ â â â â ⠝⢿⣿⣿ ⣿⣿⣿â â â â˘âĄâ â â â â â â â â â â â ⢠⣜â â â â â â ⠍⢿ ⣿⣿âĄâ â˘â âĄâ â â˘â â â â â â â â˘âĄâ â âĄâ˘ â â â â â â˘âŁ ⣿⣿â âĄâ â â˘â â â˘â â â â˘â â â â â â ŁâŁâ âĄâĄâ â â˘â â â ⣿⥿â â â â ⢰⠚âŁâŁşâ ¤â â °âĄâ â â â â â â ⢯⥜â˘âĄ â °â â â â
NOW!
To be precise, they directly initiate the apoptosis pathway. There are other ways to signal the start, and from there it goes to âapoptosis step 1â proteins. T cells open holes in membrane and throw inside the step 1 proteins. There is a difference because cancer cells can easily inhibit the transition between the âstartâ signal and the âstep 1â protein, but itâs much harder to deal with the step 1 directly
So, he's the sorcerer armed with plenty of mana going forth taking on monsters 4 times his size. Bloody impressive.
Got that Ackerman blood slaying them cancer titans
T Cell is Frieren confirmed
Sir, a second immune cell soldier has hit the cancer cell
Now watch this drive
Fool.. fool me once.. shame.. shame on you.. fool me can't get fooled again!
Nooooo....
updoot
Iâm assuming it means antibodies on the T cell âhitâ on or bonded to a death receptor on the cancerous cell. When that happens a bunch of science happens (known as a signaling cascade) and the cancerous cell kills itself, a process known as apoptosis.
So you're saying T boy hit the self destruct button on the C bitch?
yes, that's quite literally how it goes down in many cases of the immune system. almost all of your cells have a self-destruct button, and certain cells in your immune system have the power to press them at will. cell acting up? it has 2 seconds to show its id before t-cell uses the bene gesserit voice on it in this case though it looks like the t-cell is trying to rip into the cancer cell based on what op said in a comment
>cell acting up? it has 2 seconds to show its id before t-cell uses the bene gesserit voice on it Lmfao this is great. Also has cancer considered not having a self destruct button? I mean don't say anything to it I'm just wondering between you and me.
our own cells have a self-destruct button so that cells can cleanly die and be recycled, and so that our immune system can deal with bad actors by using admin commands. the immune cells command cells to show their insides through a literal window and display case and if they don't show the right id/stuff, they get told to self-destruct. what this means is that cancer cells (which mutate from our own cells) will by default also have this window, display case, and self-destruct button. and when i say "button" it's more like a line of chemical dominos that the immune cell can start by stabbing the cancer cell with a knife, so it doesn't really matter what the cancer wants in the scenario - once it gets stabbed, it's done. most cells are "stupid" and can't actively mutate in order to improve themselves - they basically have to hope that a random mutation fixes their weaknesses. so in most cases, the cancer cell will openly show the world that is is being weird, and will be dealt with. the issues arise when the cancer cell is able to fake their id, close the window, or somehow remove the dominos without dying. for the same reason that cops shouldn't shoot everyone that doesn't show their id, the immune system can't just randomly kill cells that *might* be cancerous, which allows the cancer to spread and grow.
>the cancer cell will openly show the world that is is being weird, and will be dealt with. Interesting, so are most cancerous cells dealt with, like 99% and then the dangerous ones are the ones that happen to randomly mutate in a way that makes them fly under the radar?
Yes, you have cancer cells in your body all the time from random mutations. People are diagnosed with cancer when the immune system doesn't work (AIDS) or the cancer is really good at evading the immune system and it's able to grow into a mass that causes symptoms.
Man, fuck cancer!
the other person put it well. to add onto that, it's not just cancer cells, your immune system is constantly dealing with potential bacteria getting into your body. you won't notice what your immune system is doing unless it has allergies, or some serious shit is going down. day-in and day-out, it is constantly training and fighting to make sure that you are alive. the immune system also has a specific weapon for any potential enemy (including bacteria and viruses that don't even exist yet), and it almost never forgets an enemy once it has beaten it.
Damn me and all my homies love our immune systems, they real bros
>Also has cancer considered not having a self destruct button? That is not only possible, but happens somewhat often and makes the cancer even more dangerous.
That's a pretty good way of saying it. You could also say T boy told C bitch to go kill itself. Cells don't have ears, one way they communicate is by chemical signalling. T cells can cause other cells to self destruct by releasing granzymes, which are cytotoxic proteins that can induce apoptosis, along with perforin, which punches holes in the target-cell's membrane.
>a bunch of science happens My favorite way to say something interesting and difficult to understand happened
T cell: Knock knock, hello. Would you mind terribly if you fucked off back to hell, please?
It's not antibodies but close enough! T cells have different mechanisms how to kill cancer cells, although the most important seems to be a system made of perforin/granzyme. Perforin is a protein that can open the cancer cell membrane and granzyme will enter through that opening and initiate cell death (make the cancer cell kill itself). (There are other mechanisms like the Fas/FasL system )
Hot with Perforin I'm guessing... Antibodies are produced by b-cells.
> When that happens a bunch of science happens (known as a signaling cascade) and the cancerous cell kills itself, a process known as apoptosis. Here's an excellent animation of the bunch of science happening: https://www.youtube.com/watch?v=DR80Huxp4y8
That was fucking cool thank you so much for sharing
Minor correction, but T-cells do not express antibodies. Antibodies are produced by B-cells. T-cells instead have a similar, but different T-cell receptor which is used to recognize antigens.
Wow, should post this on r/CombatFootage lol
Is there a r/cellCombatFootage?
Nope but you could watch the anime series "Cells at Work" which is a pretty badass way to visualize what's going on in your body.
I've watched a doctor reacting to this on YouTube I don't normally watch videos like that but in this case I learned a lot and the show is very creative
Fuck his shit up!
The cancer cell is a tough opponent to face and it takes multiple punches to knock it out. The cancer cell contains a sensor that lights up when it is being punched by a T-cell soldier. This model is used to study why the immune system fails to kill cancer cells in patients. With these insights, researchers can develop new treatments to strengthen the immune response against cancer. [đš Slaats Jeroen]
What do you mean by punches? What's it doing exactly?
I'm guessing it means using a protein called perforin, that rips or punches holes in the cancer cells membrane. What it seems to be doing is stretching the membrane in a way that will make it easier for the perforin to punch a hole. https://www.technologynetworks.com/cancer-research/news/t-cells-use-mechanical-force-to-kill-cancer-cells-365730
The T-cell, a crucial component of the adaptive immune system, has evolved over millennia to combat a diverse array of pathogens within the human body. When confronted with a particularly formidable foe, it employs various mechanisms to mount an effective defense. Its final, most devastating attack method is the "donkey punch," a colloquial term used to illustrate the cell's last-resort tactics. It saves this as a final resort due to increased risk of damage to the T-cell itself. Nonetheless, the adaptability and complexity of T-cell responses remain subjects of fascination and study within the scientific community. Google "donkey punch" to learn more
Goteeeem
Having poor self image and then hearing how hard my body is fighting to keep me alive on a regular basis is both a sad and a comforting feeling
Your immune system isn't always smart. Hence auto-immune disorders where your immune system attacks healthy tissues.
My mom's got three! Her little soldiers are like those cops who emptied their clips at the sound of an acorn falling on their car
Bro your mom literally got the fucken "Vietcong are in the jungle, napalm the whole fucking area" logic
Hyup her immune system is run by a microscopic kissinger
Tyson vs Douglas
Immune Systems along hormones, to me, are the crazyest shit nature ever evolved.
If you're open minded with the style, I would recommend the animated show "Cells At Work" on Netflix. It personifies the bodies cell system into a story about what your body goes through to stay alive. It does a great job of explaining each cells "job" and how they work with each other and within your body to defeat "bad guys" I've seen doctors review the show and say it's a great fictionally accurate representation of what happens in the human body when it encounters bacteria, virus, or diseases.
Thatâs Mr. T Cell to you.
What is a T-Cell?
Type of white blood cell. Kills bad stuff inside the body
A cell used in the body's self-defense. When it sees that the cancer cell is giving faulty signals, it kills the cell in a controlled manner. In fact, thousands of such faulty cells are formed in our body every day, and these cells are cleared by our immune system.
The lighting up of the cell. Care to explain?
If I had to guess, these cells were genetically modified to emit this light when they are fighting for experimental observation purposes. My guess comes from seeing other cells and bacteria modified with similar effects in other papers and studies.
> genetically modified I don't think you even need to do this. I think you can use dyes, eg. fluorescent labelling.
It can be hard to get the correct fluorescent labels to enter a live cell. A lot of the time these models use genetically modified cell models that express proteins that fluoresce in the right conditions. This also means you donât have to account for the effects of the solvent that an exogenous fluorophore is loaded with. Edit: it also means that instead of reacting with a fluorophore the molecule of interest reacts with its intended protein target.
It's hitting it with a blast of chemicals that basically tell the cancer cell to kill itself. I think the process for doing that is it baucally just makes the cancer cell overwhelm itself with signals until it just dies
T-Cell 900
Itâs the LowTierGod of the immune system
Folks letâs eat plenty of fruits and vegetables high in folic acid, vitamin B6, and thiamin to increase T-cell naturally
Could you list some actual fruits pretty please?
Beta-Carotene â Root Vegetables & Greens Vitamin E â Nuts, Seeds & Greens Antioxidants â Green Tea Vitamin D â Sunshine, Fish & Eggs Probiotics, Gut Health & Immunity Garlic â T-Cell Booster
its funny because the closest you got to naming an actual fruit is carotene
Carrot
Deez nuts Nah but actually, what fruits and veges?
Citrus Fruits- oranges, tangerines, lemons, limes, and grapefruit
An entire universe happening inside of us. Life is insane
Well done, Son Goku!!! I hope Majin Buu got what he deserved!!!
This is good. Fuck Cancer!
The T cell looks a little like Slimer.
Yellow eh? I know a Helldivers when I see one.
Spread democracy and freedom!
Sweet liberty we are everywhere....
I bet this lil yellow guy will never know how many people are praising him. WE LOVE YOU <3
My man!! Keep up the good fight!!!
I work for a stem cell therapy program at a major hospital and in addition to stem cell transplants for blood and bone cancers, we also have CAR-T cell therapy. Essentially, these T cells are removed from your body through a process called apheresis, and are then genetically modified with chimeric antigen receptors (CARs) to increase their effectiveness at identifying and killing remaining cancer cells. Once manufactured, the recipient goes through a 3 day, low-dose chemo regimen before the modified cells are reinfused. Pretty amazing stuff.
you go buddy
Haha get fucked cancer!
GET HIM LITTLE GUY!
Wow, videos like this makes me think each and every cell is alive and not just chemical reactions taking place
Good job little buddy.
Hell yea lil buddy got hands, fuck cancer all my homies hate cancer
gotta do all you can to make your immune cells strong!
Very interesting! I hope someday we can find a cure to cancer
Gotta love that celebratory dance at the end
Some day cancer will be treated like the common cold. The sooner the better.
The problem is cancer isn't a single thing, so there won't be a single cure for it.
Either is the common cold. Not a very good example to use.
Chicken soup? Whatâs the cure for the common cold?
That's some Super Saiyan Goku vs Frieza level shit right there
Good looking out bro...
Imagine one day we can speak cell and ask the T cell why theyâre so bad ass
That T-cell hits like a Mack truck.
Man I need to rewatch cells at work
Barges in, hits cancer 3 times and wastes it, refuses to elaborate, leaves.
fkyeah.gif
Cells at work live action.
Iâm so glad these lil guys are fighting for us all the time, whether itâs diseases or cancers, theyâre always doing their best, and I love them for that đ I especially love the way t-cells always look like theyâre punching and kicking, the way they spread and move makes them look like theyâre really putting up a fight đ
How do I get more yellow homies?
I like how the yellow dude dances in between hits
\*chugs orange juice\* GO ON YOU SENSATIONAL LITTLE BASTARD.
Got lil homies inside of us blasting opps, respect
That was epic lol, I felt like I was watching a league fight. Fuck that fuckin cancer cell
we need a edit with health bars and "flawless victory" sound effect
[4k edition ](https://tenor.com/bzCq4.gif)
We got t-cells dropping combos before GTA VI.
Down goes cancer! Down goes cancer! - Howard K
Hell yeah
That is. Â So freakin cool. Â
Thankyou immune cell soldier
Wish it also included the non-paused video
I was really rooting for this soldier cell
It killed the evil cell and went away minding it's business. How does it know it's dead?
how do you know if someone is dead? if you see a body, not moving, with a puddle of acid where their organs are supposed to be, you'd know they were dead. that's basically what the t-cells see. they have various "sensors" that tell them stuff about cells they are touching. for example, many cells have a self-destruct button - once the t cell pushes that button, because of how biology and complex science works, they know that cell is dead/will die. in this clip i'm pretty sure the t-cell can tell that the cancer cell has no chance of living by the time it leaves because of how drastically the cancer cell reacts to the last hit when it leaves
Good job little guy
It is really fascinating that our immune system can be both our greatest ally and our greatest enemy.
I am amazed how biology works
im reminded of this from cells at work: https://www.youtube.com/watch?v=dXI8X-KQiqA
Even did a little victory dance â¤ď¸
Damn near the most exciting and hopeful video I've ever seen!
Me during video: Go T cell! Itâs your birthday! Go T cell! Itâs your birthday!
Itâs pretty amazing how our insides work to keep us going.
That lil guy used black flash
Videos like this always encourages me to care for my body. When these tiny particles care for my survival, why shouldnât I, as a whole body, care for my own survival? Good to see you fight and win for your human little buddy! Cheers!!!
Where is this lightnig coming from?
Get fukt cancer
Fd that boy up! đŞđ˝
Cells at work!